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Corr I 316
Personality traits/Molecular Biology/Canli: Perhaps the most transformative element for future biological studies of personality will come from molecular biology. Personality traits have a high degree of heritability (Defries, McClearn, McGuffin et al. 2000)(1) and studies have begun to identify specific gene variations that are associated with individual differences within these traits (Reif and Lesch 2003)(2).
The most intensively studied of these gene variations is the serotonin transporter gene linked polymorphic region (5-HTTLPR), which is associated associated with neuroticism (Lesch, Bengel, Heils et al. 1996)(3) and amygdala reactivity to negative (relative to neutral) stimuli (Hariri, Mattay, Tessitore et al. 2002)(4). Our work has begun to elucidate the underlying mechanism, which we suggest involves modulation of tonic amygdala activation, which is further amplified by life stress experiences (Canli, Omura, Haas et al. 2005(5); Canli, Qiu, Omura et al. 2006(6); Canli and Lesch 2007)(7).



1. Defries, J. C., McClearn, G. E., McGuffin, P. et al. (eds.) 2000. Behavioural Genetics. New York: Worth Publishers
2. Reif, A. and Lesch K. P. 2003. Toward a molecular architecture of personality, Behavioural Brain Research 139: 1–20
3. Lesch, K. P., Bengel, D., Heils, A. et al. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region, Science 274: 1527–31
4. Hariri, A. R., Mattay, V. S., Tessitore, A. et al. 2002. Serotonin transporter genetic variation and the response of the human amygdala, Science 297: 400–3
5. Canli, T., Omura, K., Haas, W. et al. 2005. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of National Academy of Sciences USA 102: 12224–9
6. Canli, T., Qiu, M., Omura, K. et al. 2006. Neural correlates of epigenesis. Proceedings of National Academy of Sciences USA 103: 16033–8
7Canli, T. and Lesch, K. P. 2007. Long story short: the serotonin transporter in emotion regulation and social cognition. Nature Neuroscience 10: 1103–9



Turhan Canlı,“Neuroimaging of personality“, in: Corr, Ph. J. & Matthews, G. (eds.) 2009. The Cambridge handbook of Personality Psychology. New York: Cambridge University Press


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Explanation of symbols: Roman numerals indicate the source, arabic numerals indicate the page number. The corresponding books are indicated on the right hand side. ((s)…): Comment by the sender of the contribution.
The note [Author1]Vs[Author2] or [Author]Vs[term] is an addition from the Dictionary of Arguments. If a German edition is specified, the page numbers refer to this edition.
Molecular Biology
Corr I
Philip J. Corr
Gerald Matthews
The Cambridge Handbook of Personality Psychology New York 2009

Corr II
Philip J. Corr (Ed.)
Personality and Individual Differences - Revisiting the classical studies Singapore, Washington DC, Melbourne 2018


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