Molecular Genetics on Extraversion - Dictionary of Arguments
Corr I 294
Extraversion/motivation/molecular genetics/Munafò: The dopaminergic system is involved in appetitive and motivational behaviours (Comings and Blum 2000)(1), and pharmacological challenge studies indicate a relationship between dopaminergic hyperactivity and reward-seeking, as well as motivational factors associated with both Extraversion and novelty-seeking (Netter 2006)(2), suggesting that these traits may share a common neurobiological basis.
The dopamine D4 receptor (DRD4) gene is highly polymorphic, although research evaluating behavioural and psychiatric phenotypes has focused largely on a variable number of tandem repeats (VNTR) polymorphism in exon III, and in particular the presence or absence of the seven-repeat (‘long’) allele. See (Asghari, Schoots, Van Kats et al. 1994)(3), (Asghari, Sanyal, Buchwaldt et al. 1995)(4),(Ekelund, Suhonen, Jarvelin et al. 2001(5); Strobel et al. 2002)(6), (Okuyama, Ishiguro, Toru and Arinami 1999(7); Ronai, Barta, Guttman et al. 2001)(8).
1. Comings, D. E. and Blum, K. 2000. Reward deficiency syndrome: genetic aspects of behavioural disorders, Progress in Brain Research 126: 325–41
2. Netter, P. 2006. Dopamine challenge tests as an indicator of psychological traits, Human Psychopharmacology 21: 91–9
3 .Asghari, V., Schoots, O., Van Kats, S., Ohara, K., Jovanovic, V., Guan, H. C. et al. 1994. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes, Molecular Pharmacology 46: 364–73
4. Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V. and Van Tol, H. H. 1995. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants, Journal of Neurochemistry 65: 1157–65
5. Ekelund, J., Suhonen, J., Jarvelin, M. R., Peltonen, L., Lichtermann, D. 2001. No association of the -521 C/T polymorphism in the promoter of DRD4 with novelty seeking, Molecular Psychiatry 6: 618–19
6. Strobel, A., Lesch, K. P., Hohenberger, K., Jatzke, S., Gutzeit, H. O., Anacker, K., Brocke, B. 2002. No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking, Molecular Psychiatry 7: 537–8
7. Okuyama, Y., Ishiguro, H., Toru, M. and Arinami, T. 1999. A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia, Biochemical and Biophysical Research Communications 258: 292–5
8. Ronai, Z., Barta, C., Guttman, A., Lakatos, K., Gervai, J., Staub, M. and Sasvari-Szekely, M. 2001. Genotyping the -521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene, Electrophoresis 22: 1102–5
Marcus R. Munafò,“Behavioural genetics: from variance to DNA“, in: Corr, Ph. J. & Matthews, G. (eds.)2009. The Cambridge handbook of Personality Psychology. New York: Cambridge University Press_____________Explanation of symbols: Roman numerals indicate the source, arabic numerals indicate the page number. The corresponding books are indicated on the right hand side. ((s)…): Comment by the sender of the contribution. Translations: Dictionary of Arguments The note [Author1]Vs[Author2] or [Author]Vs[term] is an addition from the Dictionary of Arguments. If a German edition is specified, the page numbers refer to this edition.
Philip J. Corr
The Cambridge Handbook of Personality Psychology New York 2009
Philip J. Corr (Ed.)
Personality and Individual Differences - Revisiting the classical studies Singapore, Washington DC, Melbourne 2018